Activating Mutations in HER2: Neu Opportunities and Neu Challenges
نویسندگان
چکیده
منابع مشابه
Activating mutations in HER2: neu opportunities and neu challenges.
Twenty-five years after the publication of seminal studies showing that HER2 gene amplification and protein overexpression are oncogenic in breast cancer, Bose and colleagues report on the identification of activating HER2 somatic mutations that, albeit rare, may determine the response of breast cancer cells to anti-HER2 agents. These results herald a new era for the potential use of existing H...
متن کاملIN THE SPOTLIGHT Activating Mutations in HER2 : Neu Opportunities and Neu Challenges
Authors’ Affi liation: Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York Corresponding Author: Jorge S. Reis-Filho, Department of Pathology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065. Phone: 212-639-8054; Fax: 212-772-8521; E-mail: reisfi lj@ mskcc.org doi: 10.1158/2159-8290.CD-12-0585 ©2012 American Association for Cancer Res...
متن کاملDown-regulation of HER2/neu expression induces apoptosis in human cancer cells that overexpress HER2/neu.
The HER2/neu oncogene is overexpressed in a significant fraction of human tumors; such overexpression is thought to play a role in the aberrant proliferation of cancer cells. The effects of HER2/neu-specific phosphorothioate antisense oligodeoxyribonucleotides on HER2/neu expression, tumor cell proliferation, and activation of apoptotic cell death pathways have been examined. Antisense treatmen...
متن کاملHer2-neu: a target in lung cancer?
In addition to the steady flow of new cytotoxic drugs for lung cancer during the last decade, the elegant concept of targeted agents has in recent years become a source of optimism and pitfalls. Among all the targets, Her2-neu is a typical example of how preclinical data can be translated into clinical progress. Her2-neu in breast cancer: the ideal model Erb-B2 (Her2-neu) is a 185 kDa glycoprot...
متن کاملAmplification and overexpression of HER2/neu gene and HER2/neu protein in salivary duct carcinoma of the parotid gland.
OBJECTIVES To detect amplification of the HER2/neu gene by means of fluorescence in situ hybridization (FISH) in a series of 13 salivary duct carcinomas (SDCs) and to compare the results with immunohistochemical (IHC) assessment of HER2/neu protein expression. DESIGN Retrospective analysis. SETTING Department of Pathology, University of Brescia. PATIENTS We studied 13 cases of SDC diagnos...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer Discovery
سال: 2013
ISSN: 2159-8274,2159-8290
DOI: 10.1158/2159-8290.cd-12-0585